Sex-specific demographic behaviours that shape human genomic variation

Sex-Biased Evolutionary Forces Shape Genomic Patterns of Human Diversity

Comparisons of levels of variability on the autosomes and X chromosome can be used to test hypotheses about factors influencing patterns of genomic variation. While a tremendous amount of nucleotide sequence data from across the genome is now available for multiple human populations, there has been no systematic effort to examine relative levels of neutral polymorphism on the X chromosome versu...

Human evolution: Sex-specific contributions to genome variation

Studies of maternally-inherited mitochondrial DNA have provided evidence that all modern humans have a common, 200,000 year old African ancestor. Recent studies of Y chromosome variation support this view and suggest that males and females have contributed differentially to human genome variation.

Identification of Human Chromosome Segments that Have High Homology with Rat Genomic DNA

This study was conducted to determine the location of DNA segment with homology to the rat conserved genomic DNA in human chromosomes. The labeled rat genomic DNA was hybridized with normal human (male) metaphases. The study of 74 metaphases after fluorescence in situ hybridization showed 371 twin-spot signals on human chromosomes. Statistical analysis indicated that the specific accumulation o...

Human-Specific Genomic Events

Conservation of Regional Variation in Sex-Specific Sex Chromosome Regulation.

Regional variation in sex-specific gene regulation has been observed across sex chromosomes in a range of animals and is often a function of sex chromosome age. The avian Z chromosome exhibits substantial regional variation in sex-specific regulation, where older regions show elevated levels of male-biased expression. Distinct sex-specific regulation also has been observed across the male hyper...